The next sections on pathogenesis provide a comprehensive reference on how henipaviruses counteract the innate immune system, and the relevant pathogenic features in animal challenge models developed to test potential therapeutic strategies. It is an international effort written by a multidisciplinary panel of experts at the front lines of research into this lethal emerging group of paramyxoviruses. It is an international effort written by a multidisciplinary panel of experts at the front lines of research into this lethal emerging group of paramyxoviruses. In collaboration with stem cell biologists, we have developed an armamentarium of tools based on the picomolar affinity of NiV-G for EphrinB2 to interrogate the role of ephrinB2 in human pluripotent stem cell fate and differentiation. For example, a recent focus of our lab is developing that target either viral or host cell components that are essential for multiple classes of virus.
Physicians and scientists on the faculty of the Icahn School of Medicine at Mount Sinai often interact with pharmaceutical, device and biotechnology companies to improve patient care, develop new therapies and achieve scientific breakthroughs. . Infect Disord Drug Targets, 11:3. Description: 1 online resource : illustrations chiefly color. Although henipavirus spillover events are currently limited to Southeast Asia and Australia, a recent global survey of almost 5,000 bat specimens revealed at least 23 distinct viral clades within the henipavirus genus, with the known Nipah and Hendra viruses representing only two of those clades1. Importantly, these biophysical changes are not found in biogenic cellular membranes treated with antiviral concentrations of the compound, likely due to multiple endogenous mechanisms that protect lipids against oxidative damage. Henipavirus Lee Benhur Rota Paul A can be very useful guide, and henipavirus lee benhur rota paul a play an important role in your products.
Vigant F, Jung M, Lee B. Geisbert, Kai Xu, Dimitar B. J Gen Virol, 91:Pt 3. The guiding objective of our research is to obtain and translate basic knowledge about viral entry and replication processes to therapeutic or interventional anti-viral strategies. For a more detailed introduction, please refer to Henipavirus: Ecology, Molecular Biology and Pathogenesis Benhur Lee and Paul Rota, Editors, Current Topics in Microbiology and Immunology.
In many cases, the estimated time from infection to death is less than 2 weeks, with symptomatic periods lasting for 4-7 days. Proc Natl Acad Sci U S A, 107:7. The first section introduces the epidemiology and ecology of Nipah and Hendra viruses in their respective endemic areas, including a first-hand account of the discovery of Nipah virus during its initial outbreak in Malaysia; the next section documents the molecular virology of henipaviruses, and the substantial advances made towards understanding the unique features of henipavirus entry and tropism; and this is followed by accounts of the clinical and pathologic features of henipavirus infections in their human and naturally infected animal hosts. We study highly pathogenic viruses, and use the and as primary model systems to represent the pathogenesis of acute and chronic viruses, respectively. Henipavirus is a new genus of paramyxovirus discovered around the turn of the 20th century.
Role of cooperativity between residues in N-terminal extracellular and intracellular domains. For details on the Affinofle system, please see for the original description. Patients may wish to ask their physician about the activities they perform for companies. Proc Natl Acad Sci U S A, 94:26. How viruses survive, proliferate and transmit within and between hosts is a testament to the past and present evolutionary battles between host and pathogen. The final sections describe our current and future capabilities for diagnosis and control, including an account of potentially effective immunization strategies that are currently being tested.
Mount Sinai's faculty policies relating to faculty collaboration with industry are posted on our. Introduction: Nipah virus : discovery and Origin. Vigant F, Jung M, Lee B. Samal The Biology of Paramyxoviruses edited by Siba K. Nat Struct Mol Biol, 15:6.
This volume deals with the many facets of henipavirus biology, and covers our current understanding regarding the ecology, molecular virology, and pathogenesis of henipavirus infections. The problem is that once you have gotten your nifty new product, the henipavirus lee benhur rota paul a gets a brief glance, maybe a once over, but it often tends to get discarded or lost with the original packaging. In addition, he has research contracts for generating targeted lentiviral vectors for crossing the blood-brain-barrier; once again, using insights gained from basic studies into virus entry and tropism. The phylogenetic diversity of henipaviruses is thus vastly greater than what was thought previously. Lee graduated from Yale University School of Medicine in 1995 with an M. A recent focus in our lab is developing that target either viral or host cell components that are essential for multiple classes of virus.
It is an international effort written by a multidisciplinary panel of experts at the front lines of research into this lethal emerging group of paramyxoviruses. Nipah NiV and Hendra HeV virus are zoonotic viruses--transmitted to humans from their natural bat reservoir--that cause fatal encephalitis in 40-75% of infected patients. Bioactive Proteasome Inhibitors Our basic studies on Nipah virus budding led us to discover that ubiquitin-regulated nuclear-cytoplasmic trafficking of the Nipah virus matrix NiV-M protein is critical for matrix budding function. Prior to his recruitment to Mount Sinai, Dr. Proc Natl Acad Sci U S A, 96:9.
Protocols will be published on our lab's web-site, as and when they are published in the peer reviewed literature. We are particularly interested in developing novel methods, reagents, and therapeutics to address long-standing and intractable problems in our fields of interest. Henipaviruses form a new genus of emerging paramyxoviruses that are the deadliest human pathogens within the Paramyxoviridae family. The next sections on pathogenesis provide a comprehensive reference on how henipaviruses counteract the innate immune system, and the relevant pathogenic features in animal challenge models developed to test potential therapeutic strategies. Click for a quick introduction to.
Our laboratory4, and others5, independently discovered EphrinB2 as the major receptor for Nipah and Hendra virus entry. In addition, arenaviruses, hantaviruses, dengue and chikungunya viruses may even be considered as diseases of global warming as climate change increases the geographical range of their animal or arthropod hosts. Non-Peer Reviewed Publications The Biology of Paramyxoviruses edited by Siba K. Ebola and Marburg viruses filioviruses , and Hendra and Nipah viruses henipaviruses are the most lethal examples of recent zoonoses. This results in changes in the biophysical properties of viral membranes that are not conducive for the membrane curvature dynamics required for productive viral-cell fusion. This book will not only serve as a useful reference for the henipavirus field; it will be useful to basic and animal virologists, ecologists, epidemiologists, physicians, and others interested in emerging infectious viral diseases, as it showcases the multidisciplinary efforts required to understand the genesis, spread and hopefully, control, of a group of lethal emerging zoonotic pathogens. Please note that this information may differ from information posted on corporate sites due to timing or classification differences.