Small molecule inhibitors of protein protein interactions fry david vassilev lyubomir. Indigo 2019-03-16

Small molecule inhibitors of protein protein interactions fry david vassilev lyubomir Rating: 5,1/10 1311 reviews

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small molecule inhibitors of protein protein interactions fry david vassilev lyubomir

The content of the articles is rich, and in terms of scope ranges from generalized approaches to specific case studies. Keywords:Protein–Protein Interactions;Protein–Protein Complexes;Protein Design;Binding Interface, Protein Evolution;Structural Bioinformatics;Protein Interaction NetworkKey Features:Covers protein—protein interactions at the structural level in great detailDescribes the structure of protein—protein complexes, and also gives insight into the mechanism of complex formation and the forces that drive complex formationCovers to some degree the emerging field of designing new protein—protein interactions, i. There are various focal points, including methodologies and the molecules themselves. Readership: Graduate students and researchers in bioinformatics and computational biology, biophysics, biochemistry, structural biology, and drug design. Update your browser to continue using indigo. Tailor-made for the practicing medicinal chemist, this ready reference includes a wide selection of case studies taken straight from the development pipeline of major pharmaceutical companies to illustrate the power and potential of this approach.

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Indigo

small molecule inhibitors of protein protein interactions fry david vassilev lyubomir

The content of the articles is rich, and in terms of scope ranges from generalized approaches to specific case studies. Reviews the strategies, technologies, principles, and applications of modern medicinal chemistry Provides a global and current perspective of today's drug discovery process and discusses the major therapeutic classes and targets Includes a unique collection of case studies and personal assays reviewing the discovery and development of key drugs Category: Science Author : Michael D. The content of the articles is rich, and in terms of scope ranges from generalized approaches to specific case studies. In this volume, the editors have collected the knowledgeable insights of a number of leaders in this field - researchers who have achieved success in addressing the difficult problem of inhibiting protein-protein interactions. There are various focal points, including methodologies and the molecules themselves. The review focuses on the compounds with most available data within the literature and discusses both the anti-cancer and the recently unveiled anti-angiogenic potential of this new class of drugs. The content of the articles is rich, and in terms of scope ranges from generalized approaches to specific case studies.

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Indigo

small molecule inhibitors of protein protein interactions fry david vassilev lyubomir

The content of the articles is rich, and in terms of scope ranges from generalized approaches to specific case studies. For providing our services, we do use cookies. Pour continuer à magasiner sur Indigo. Small-molecule Inhibitors of Protein—Protein Interactions T Berg Protein Dynamics and Drug Design: The Role of Molecular Simulations G Morra et al. There are various focal points, including methodologies and the molecules themselves. Ultimately, there are numerous lessons to be taken away from this collection, and the editors hope that this snapshot of the current state of the art in developing protein-protein inhibitors not only pays tribute to the past successes, but also generates excitement about the future potential of this field.

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9783642170829

small molecule inhibitors of protein protein interactions fry david vassilev lyubomir

In this volume, the editors have collected the knowledgeable insights of a number of leaders in this field-researchers who have achieved success in addressing the difficult problem of inhibiting protein-protein interactions. It focuses on what can be learned about protein—protein interactions from the analysis of protein—protein complex structures and interfaces. The discipline of medicinal chemistry continues to evolve as it adapts to new opportunities and strives to solve new challenges. These researchers describe their unique approaches, and share experiences, results, thoughts, and opinions. These researchers describe their unique approaches, and share experiences, results, thoughts, and opinions.

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Small

small molecule inhibitors of protein protein interactions fry david vassilev lyubomir

Bookseller: , California, United States. The main part of the book describes examples of protein targets for which small molecule modulators have been developed, covering such diverse fields as cancer, autoimmune disorders and infectious diseases. Ultimately, there are numerous lessons to be taken away from this collection, and the editors hope that this snapshot of the current state of the art in developing protein-protein inhibitors not only pays tribute to the past successes, but also generates excitement about the future potential of this field Small-Molecule Inhibitors of Protein-Protein Interactions 3 Preface 5 Contents 7 Contributors 9 Hydrogen-Bonded Synthetic Mimics of Protein Secondary Structure as Disruptors of Protein-Protein Interactions 11 1 Introduction 12 2 a-Helix Mimicry 12 2. To continue shopping at Indigo. Buying eBooks from abroad For tax law reasons we can sell eBooks just within Germany and Switzerland. Veuillez effectuer une mise Ă  jour de votre navigateur pour continuer sur Indigo. These researchers describe their unique approaches, and share experiences, results, thoughts, and opinions.

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9783642170829

small molecule inhibitors of protein protein interactions fry david vassilev lyubomir

Contents: X-ray Study of Protein—Protein Complexes and Analysis of Interfaces J Janin A Structural Perspective on Protein—Protein Interactions in Macromolecular Assemblies R P Bahadur Energetics of Protein—Protein Interactions I Jelezarov Kinetics of Biomacromolecular Complex Formation: Theory and Experiment G V Pachov et al. Description Cancer has a complex etiology and displays a wide range of cellular escape pathways that allow it to circumvent treatment. How can we extract the mechanism of specific recognition from studying protein—protein interfaces? Bcl-2, a pro-survival signaling molecule, is one such protein. Arora Rational Design Strategies for Developing Synthetic Inhibitors of Helical Protein Interfaces Michael D. There are various focal points, including methodologies and the molecules themselves.

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eBook: Small

small molecule inhibitors of protein protein interactions fry david vassilev lyubomir

But get used, this is what most of modern web do! These researchers describe their unique approaches, and share experiences, results, thoughts, and opinions. This book has broad appeal and is of significant interest to the pharmaceutical science and medicinal chemistry communities. These include drug targeting, biomolecular therapeutics, development of chemical biology tools, data collection and analysis, in silico models as predictors for biological properties, identification and validation of new targets, approaches to quantify target engagement, new methods for synthesis of drug candidates such as green chemistry, development of novel scaffolds for drug discovery, and the role of regulatory agencies in drug discovery. Mit dem amazon-Kindle ist es aber nicht kompatibel. Ultimately, there are numerous lessons to be taken away from this collection, and the editors hope that this snapshot of the current state of the art in developing protein-protein inhibitors not only pays tribute to the past successes, but also generates excitement about the future potential of this field. What methods are currently employed to design protein—protein interactions, and how can we influence protein—protein interactions by mutagenesis and small-molecule drugs or peptide mimetics? Ultimately, there are numerous lessons to be taken away from this collection, and the editors hope that this snapshot of the current state of the art in developing protein-protein inhibitors not only pays tribute to the past successes, but also generates excitement about the future potential of this field. Regrettably we cannot fulfill eBook-orders from other countries.

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Small

small molecule inhibitors of protein protein interactions fry david vassilev lyubomir

In this volume, the editors have collected the knowledgeable insights of a number of leaders in this field - researchers who have achieved success in addressing the difficult problem of inhibiting protein-protein interactions. These researchers describe their unique approaches, and share experiences, results, thoughts, and opinions. This book does just that. . How can this knowledge be used to predict and design protein—protein interactions interaction regions and complex structures? Very good in very good dust jacket. This review examines the efficacy, potency, and function of several small molecule inhibitor drugs targeted to the Bcl-2 family of proteins. By continuing to use this site, you agree to allow us to store cookies on your computer.

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